ME-3229

Chemical Name: 2,2'-[4-[2-(4,5,6,7-Tetrahydrothieno[3,2-c]pyridin-2-ylcarboxamido)acetyl]-1,2-phenylene]bis(oxy)bis(acetic acid) dibutyl ester
CAS No. 165949-40-6, 165949-41-7 (monotrifluoroacetate)
项目整合开发状态: Preclinical
项目研究机构: Meiji Seika (Originator)
合成路线:Treatment of 4,5,6,7-tetrahydrothieno[3,2-c]pyridin-2-carboxylic acid (I) with di-tert-butyl dicarbonate and triethylamine provided the N-Boc derivative (II),which was subsequently coupled with di-n-butyl [[4-(aminoacetyl)-o-phenylene]dioxy]diacetate (III) using BOP and N-methylmorpholine to afford amide (IV).The Boc protecting group of (IV) was finally cleaved by treatment with trifluoroacetic acid in the presence of anisole.