NBI-27155
Chemical Name: N-(Dicyclopropylmethyl)-N-propyl-N-[4-(2,4,6-trimethoxyphenyl)pyrimidin-2-yl]amine
CAS No. 186342-55-2
项目整合开发状态: Preclinical
项目研究机构: Neurocrine Biosciences (Originator)
合成路线:2',4',6'-Trimethoxyacetophenone (I) was condensed with dimethylformamide dimethylacetal (II) in refluxing DMF to afford the enamino ketone (III).Subsequent cyclization of (III) with N1-dicyclopropylmethyl-N1-propyl-guanidine hydrochloride (IV) in the presence of t-BuOK produced the target pyrimidine.
📌 参考资料/链接：
参考文献标题:Amino-substd.thiadiazoles,pyrimidines,triazines or triazoles useful as CTF receptor antagonists
文献作者:McCarthy,J.R.; Xie,Y.F.; Whitten,J.P.; Webb,T.R.; Chen,C.; Ramphal,J.Y.; Grigoriadis,D.E.; Dagnino,R.Jr.; Huang,C.Q.; Liu,Z.(Neurocrine Biosciences Inc.)
参考来源:EP 0846108; JP 1999507358; US 5795905; WO 9639400