Mivacurium chloride, BW-B1090U, Mivacron
米库氯铵Chemical Name: (E)-(1R,1'R)-2,2'-[4-Octenedioylbis(oxytrimethylene)]bis[6,7-dimethoxy-2-methyl-1-(3,4,5-trimethoxybenzyl)-1,2,3,4-tetrahydroisoquinolinium] dichloride; [R-[R*,R*-(E)]]-2,2'-[(1,8-Dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl)]bis[1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-[(3,4,5-trimethoxyphenyl)methyl]isoquinolinium] dichloride
CAS No. 106861-44-3
项目整合开发状态: Launched-1992
项目研究机构: Abbott (Proprietary), GlaxoSmithKline (Originator)
合成路线:The optical resolution of (?-5'-methoxylaudanosine with (-)-dibenzoyltartaric acid in methanol gives (R)-(-)-5'-methoxylaudanosine (I),which is condensed with 3-chloropropanol (II) by means of NaI and Na2CO3 in refluxing butanone yielding the quinolinium chloride derivative (III).Finally,this compound is esterified with 4(E)-octenedioyl chloride (IV) in hot 1,2-dichloroethane.
📌 参考资料/链接：
参考文献标题:Bis-dimethoxymethyl(trimethoxybenzyl)isoquinolinium salts,their preparation and pharmaceutical compsns.containing them
文献作者:Swaringen,R.A.Jr.; El-Sayad,H.A.; Yeowell,D.A.; Savarese,J.J.(General Hospital Corporation; GlaxoSmithKline plc)
参考来源:EP 0181055; ES 8609260; JP 1986087666; JP 1986087666; US 4761419
📄 详细内容
合成路线:The optical resolution of (?-5'-methoxylaudanosine with (-)-dibenzoyltartaric acid in methanol gives (R)-(-)-5'-methoxylaudanosine (I),which is condensed with 3-chloropropanol (II) by means of NaI and Na2CO3 in refluxing butanone yielding the quinolinium chloride derivative (III).Finally,this compound is esterified with 4(E)-octenedioyl chloride (IV) in hot 1,2-dichloroethane.
参考文献标题:MIVACURIUM CHLORIDE < Rec INN; BAN >
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(7),632
产品链接: CAS No. 106861-44-3››