合成路线:Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II,X = halo) or dimethyl sulfate (II,X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III),which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form).After crystallization from ethanol the inner salt is obtained as a dihydrate.
参考文献标题:3-(2,2,2-Trimethylhydrazinium)propionate,process for their preparation and use
文献作者:Eremeev,A.V.; Kalvinsh,V.G.; Semenikhina,V.G.; Liepinsh,E.E.; Latvietis,Y.Y.; Anderson,P.P.; Astapenok,F.B.; Spuzh,Y.Y.; Trapentsiers,G.T.; Podoprigora,G.I.; Giller,S.A.(Latvian Institute of Organic Synthesis)
参考来源:FR 2478087
合成路线:Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II,X = halo) or dimethyl sulfate (II,X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III),which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form).After crystallization from ethanol the inner salt is obtained as a dihydrate.
参考文献标题:MILDRONATE
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1989,14(1),29
合成路线:Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II,X = halo) or dimethyl sulfate (II,X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III),which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form).After crystallization from ethanol the inner salt is obtained as a dihydrate.
参考文献标题:Molecular-crystalline structure of 3-(2,2,2-trimethylhydrazinio)propionate dihydrate C6H14N2O2.2H2O
文献作者:Kemme,A.; Bleidelis,J.; Kalvins,I.; Eremeev,A.V.
参考来源:Latv Psr Zinat Akad Vestis 1983,2215-8
合成路线:Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II,X = halo) or dimethyl sulfate (II,X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III),which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form).After crystallization from ethanol the inner salt is obtained as a dihydrate.
参考文献标题:
文献作者:Bremanis,G.; Shimanskaya,M.V.; Lukevicz,E.Ya.; Kalvinsh,I.Ya.; Goldberg,Yu.Sh.; Abele,E.
参考来源:Dokl Akad Nauk SSSR (Khim) 1987,2941387
合成路线:Methyl 3-(2,2-dimethylhydrazino)propionate (I) is treated with a methyl halide (II,X = halo) or dimethyl sulfate (II,X = CH3SO4) to give the appropriate trimethylhydrazinium salt (III),which is transferred to 3-(2,2,2-trimethylhydrazinium)propionate (IV) by Amberlite IRA-400 (OH form).After crystallization from ethanol the inner salt is obtained as a dihydrate.
参考文献标题:Treatment of cardiovascular diseases with 3-(2,2,2-trimethylhydrazinium) propionate dihydrate.
文献作者:Kalvinsh,I.Y.; Vinogradov,A.V.; Veveris,M.M.; Makarova,I.I.; Birman,A.S.; Barmotin,G.V.; Akifiev,O.N.(Institu Orch Sinteza Akademii)
参考来源:DE 3234537; GB 2105992; JP 58074606; US 4451485
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