RSD-992
Chemical Name: 1-(4-Methylpiperazin-1-yl)-2-(2-naphthyl)ethanone hydrochloride
CAS No. 219901-21-0, 219901-24-3 (free base)
项目整合开发状态: Preclinical
项目研究机构: Cardiome (Originator), Xoma (Not Determined)
合成路线:2-(2-Naphthyl)acetic acid (I) is activated as the corresponding acid chloride (II) upon refluxing with SOCl2.Subsequent condensation of acid chloride (II) with N-methyl piperazine (III) affords the title amide.
📌 参考资料/链接：
参考文献标题:Serotonin ligands as pro-erectile cpds.
文献作者:Hayes,E.S.(Cardiome Pharma Corp.)
参考来源:WO 0028993
📄 详细内容
合成路线:2-(2-Naphthyl)acetic acid (I) is activated as the corresponding acid chloride (II) upon refluxing with SOCl2.Subsequent condensation of acid chloride (II) with N-methyl piperazine (III) affords the title amide.
参考文献标题:Aroylpiperazines for modulating sexual activity
文献作者:Zolotoy,A.B.; Hayes,E.S.(Cardiome Pharma Corp.)
参考来源:WO 9902159