MS-31-050

Chemical Name: N1-[5,7-Dimethoxy-2-(2-methylphenyl)quinolin-4-ylcarbonyl]guanidine dihydrochloride
CAS No. 181048-29-3 (free base)
项目整合开发状态: Preclinical
项目研究机构: Mitsui Chemicals (Originator)
合成路线:Quinoline (IV) was prepared by condensation of 3,5-dimethoxyaniline (I),pyruvic acid (II) and o-tolualdehyde (III) in refluxing EtOH.After activation of (IV) as the acid chloride (V) by means of SOCl2 in benzene,its condensation with guanidine (VI) in DMF yielded the corresponding acyl guanidine.

合成路线:Quinoline (IV) was prepared by condensation of 2-(2-methoxyethyl)aniline (I),pyruvic acid (II) and benzaldehyde (III) in refluxing EtOH.After activation of (IV) as the imidazolide (V) by means of 1,1'-carbonyldiimidazole in DMF,its condensation with guanidine (VI) in the same solvent yielded the corresponding acyl guanidine.