AT-760
Chemical Name: 6,6'-(1,4-Phenylene)bis[(E)-vinylene]bis(carbonyl)bis[8(S)-(chloromethyl)-4-hydroxy-2-(trifluoromethyl)-3,6,7,8-tetrahydrobenzo[1,2-b:4,3-b']dipyrrole-1-carboxylic acid methyl ester]
CAS No. 179693-47-1
项目整合开发状态: Preclinical
项目研究机构: Kyorin (Originator), Sagami (Originator)
合成路线:Deprotection of tert-butoxycarbonyl group of (S)-pyrroloindole (I) by treatment with 3 M HCl in EtOAc afforded amine (II).Then,coupling two equivalents of amine (II) with one equivalent of (phenylene)diacrylic acid (III) in the presence of EDC [N-ethyl-N'-(dimethylaminopropyl)carbodiimide] provided the target bisamide.
📌 参考资料/链接：
参考文献标题:The novel cyclopropapyrroloindole (CPI) bisalkylators bearing 3,3'-(1,4-phenylene)diacryloyl group as a linker
文献作者:Fukuda,Y.; Seto,S.; Furuta,H.; Ebisu,H.; Oomori,Y.; Terashima,S.
参考来源:Bioorg Med Chem Lett 1998,8(15),2003-2004
📄 详细内容
合成路线:Deprotection of tert-butoxycarbonyl group of (S)-pyrroloindole (I) by treatment with 3 M HCl in EtOAc afforded amine (II).Then,coupling two equivalents of amine (II) with one equivalent of (phenylene)diacrylic acid (III) in the presence of EDC [N-ethyl-N'-(dimethylaminopropyl)carbodiimide] provided the target bisamide.
参考文献标题:Novel seco cycloproal[c]pyrrolo [3,2-e]indole bisalkylators bearing a 3,3'-arylenebisacryloylm group as a liker
文献作者:Fukuda,Y.; Seto,S.; Furuta,H.; Ebisu,H.; Oomori,Y.; Terashima,S.
参考来源:J Med Chem 2001,44(9),1396