MF-8622

Chemical Name: N-[4-(4-Morpholinyl)butyl]carbamic acid 3-[2-(dimethylamino)-1,1-dimethylethyl]phenyl ester bitartrate
CAS No. 177338-89-5 (free base)
项目整合开发状态: Preclinical
项目研究机构: Mediolanum (Originator)
合成路线:The reductomethylation of 2-(3-methoxyphenyl)-2-methylpropylamine (I) with formaldehyde and sodium cyanoborohydride in acetonitrile gives the dimethylamino compound (II),which is treated with refluxing 48% HBr to yield the phenol (III).Finally,this compound is condensed with 4-(4-morpholinyl)butyl isocyanate (IV) by means of Na in toluene.The intermediate isocyanate (IV) has been obtained by reaction of 4-(4-morpholinyl)butylamine with phosgene and triethylamine in toluene.