Mivotilate, YH-439
Chemical Name: 2-(1,3-Dithietan-2-ylidene)-2-[N-(4-methylthiazol-2-yl)carbamoyl]acetic acid isopropyl ester
CAS No. 130112-42-4
项目整合开发状态: Discontinued
项目研究机构: Yuhan (Originator), Grelan (Licensee)
合成路线:Partial hydrolysis of diisopropyl ester (I) with KOH at room temperature gives the monoacid (II).Treatment of this acid with ethyl chloroformate in the presence of triethylamine affords the mixed anhydride (III),which is then condensed with 2-amino-4-methylthiazole (IV).
📌 参考资料/链接：
参考文献标题:Pharmaceutically active dithioketene derivs.
文献作者:Kim,C.S.; Chae,J.S.; Yoo,H.S.; Park,J.G.; Lee,J.W.(Yuhan Corp.)
参考来源:EP 0366614