YM-49244

Chemical Name: 1'-[2-[3-(3,4-Dichlorophenyl)-1-[2-[3-(isopropoxy)phenyl]acetyl]piperidin-3-yl]ethyl]-1'-methyl-3-oxospiro[1,2,3,4-tetrahydroisoquinoline-1,4'-piperidinium] iodide
CAS No. 173941-19-0
项目整合开发状态: Preclinical
项目研究机构: Yamanouchi (Originator)
合成路线:The known piperidinoethanol derivative (I) was converted to the mesylate (II) upon treatment with methanesulfonyl chloride and triethylamine.Displacement of the mesylate group of (II) with the spiro-substituted piperidine (III) provided adduct (IV).Finally,quaternization of piperidine (IV) with iodomethane gave the corresponding ammonium salt as a mixture of cis/trans isomers that were separated by column chromatography.