PD-146626
Chemical Name: 9-Methoxy-2,3,4,5-tetrahydro[1]benzothieno[2,3-f]-1,4-thiazepin-5-one
CAS No. 172832-10-9
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:Methyl 3-chloro-5-methoxybenzo[b]thiophene-2-carboxylate (II) was prepared from the known acid chloride (I) by treatment with methanol.Cyclization of the chloro ester (II) with cysteamine hydrochloride (III) in the presence of DBU afforded the target benzothienothiazepinone.
📌 参考资料/链接：
参考文献标题:Benzothiophene,benzofuran and indolethiazepinones,oxazepinones and diazepinones as inhibitors of cell adhesion and as inhibitors of HIV
文献作者:Boschelli,D.H.; Connor,D.T.; Kramer,J.B.; Unangst,P.C.(Pfizer Inc.)
参考来源:EP 0749434; JP 1997509961; US 5489586; WO 9524408
📄 详细内容
合成路线:Methyl 3-chloro-5-methoxybenzo[b]thiophene-2-carboxylate (II) was prepared from the known acid chloride (I) by treatment with methanol.Cyclization of the chloro ester (II) with cysteamine hydrochloride (III) in the presence of DBU afforded the target benzothienothiazepinone.
参考文献标题:Use of thiazepine,oxazepine and diazepine cpds.for inhibiting HIV,herpesvirus and suppressing the immune system
文献作者:Gracheck,S.J.(Pfizer Inc.)
参考来源:EP 0817635; JP 1999502814; WO 9629077
合成路线:Methyl 3-chloro-5-methoxybenzo[b]thiophene-2-carboxylate (II) was prepared from the known acid chloride (I) by treatment with methanol.Cyclization of the chloro ester (II) with cysteamine hydrochloride (III) in the presence of DBU afforded the target benzothienothiazepinone.
参考文献标题:Preparation of benzothieno[2,3-f]-1,4-oxazepin- and -thiazepin-5(2H)-ones and of benzothieno[3,2-e]-1,4-diazepin-5-ones
文献作者:Khatana,S.S.; et al.
参考来源:J Org Chem 1996,61(17),6060
产品链接: CAS No. 172832-10-9››