Sulconazole nitrate, RS-44872, Exelderm
硝酸硫康唑 硫康唑Chemical Name: (?-1-[2,4-Dichloro-beta-[(p-chlorobenzyl)thio]phenethyl]imidazole mononitrate
CAS No. 59293-82-2, 61318-91-0, 61318-90-9 (free base)
项目整合开发状态: Launched-1985
项目研究机构: Degussa (Originator), Roche Bioscience (Originator), Bioglan (Not Determined), Schwarz (Not Determined), Tanabe Seiyaku (Licensee), Westwood (Licensee)
合成路线:The reaction of 2,4-dichlorophenacyl chloride (I) with imidazole (A) gives the ketone (II),which is reduced with sodium borohydride to yield the alcohol (III).Conversion of the alcohol (III) to the chloro derivative (IV) with thionylchloride followed by reaction with p-chlorobenzyl mercaptan (V) affords sulconazole.
📌 参考资料/链接：
参考文献标题:Sulconazole
文献作者:Arya,V.P.
参考来源:Drugs Fut 1980,5(4),206
📄 详细内容
合成路线:The reaction of 2,4-dichlorophenacyl chloride (I) with imidazole (A) gives the ketone (II),which is reduced with sodium borohydride to yield the alcohol (III).Conversion of the alcohol (III) to the chloro derivative (IV) with thionylchloride followed by reaction with p-chlorobenzyl mercaptan (V) affords sulconazole.
参考文献标题:Manufacture of novel imidazole derivative
文献作者:Keisu,E.E.U.
参考来源:AT 347449B; BE 0833614; JP 59089667; ZA 7505100
产品链接: CAS No.61318-91-0›› 产品链接: CAS No.61318-90-9››