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项目整合精选>>>Oxiconazole nitrate, Ro-13-8996/001, Sgd-30176, Okinazole, Oxistat, Myfungar, Oceral
Oxiconazole nitrate, Ro-13-8996/001, Sgd-30176, Okinazole, Oxistat, Myfungar, Oceral
硝酸奥昔康唑 奥昔糠唑 Chemical Name: 2',4'-Dichloro-2-(1H-imidazol-1-yl)acetophenone (Z)-[O-(3,4-dichlorobenzyl)oxime] mononitrate; 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-1-yl)ethanone (Z)-O-[(2,4-dichlorophenyl)methyl]oxime mononitrate
CAS No. 64211-46-7, 64211-45-6 (free base)
项目整合开发状态: Launched-1983
项目研究机构: Roche (Originator), Yamanouchi (Not Determined), GlaxoSmithKline (Licensee), Mitsubishi Pharma (Licensee), Elan (Distributor)
合成路线:The reaction of 2',4'-dichloro-2-imidazol-1-yl-acetophenone (I) with hydroxylamine (II) in refluxing ethanol pyridine gives the corresponding oxime (III).which is condensed with 2,4-dichlorobenzyl chloride (IV) by means of NaH in hot DMF.
📌 参考资料/链接：
参考文献标题:Imidazolyl-oxime ethers having anti-mycotic and bactericidal activity
文献作者:Mixich,G.; et al.(Siegfried AG)
参考来源:DE 2657578; FR 2336129; GB 1514870; JP 52102276; US 4124767
📄 详细内容
合成路线:The reaction of 2',4'-dichloro-2-imidazol-1-yl-acetophenone (I) with hydroxylamine (II) in refluxing ethanol pyridine gives the corresponding oxime (III).which is condensed with 2,4-dichlorobenzyl chloride (IV) by means of NaH in hot DMF.
参考文献标题:Oxiconazole nitrate
文献作者:Serradell,M.N.; Blancafort,P.; Hillier,K.; Castar,J.
参考来源:Drugs Fut 1981,6(2),99
合成路线:The reaction of 2',4'-dichloro-2-imidazol-1-yl-acetophenone (I) with hydroxylamine (II) in refluxing ethanol pyridine gives the corresponding oxime (III).which is condensed with 2,4-dichlorobenzyl chloride (IV) by means of NaH in hot DMF.
参考文献标题:Ein beitrag zur stereospezifischen Synthese von antimykotisch wirksamen imidazolyloximathern
文献作者:Thiele,K.; Mixich,G.
参考来源:Arzneim-Forsch Drug Res 1979,29(10),1510-13
产品链接: CAS No. 64211-46-7›› 产品链接: CAS No.64211-45-6››