Fasudil hydrochloride, AT-877, HA-1077, Fasdil, Eril

盐酸法舒地尔 法舒地尔 Chemical Name: 1-(5-Isoquinolinesulfinyl)hexahydro-1H-1,4-diazepine hydrochloride; 1-(5-Isoquinolinesulfinyl)homopiperazine hydrochloride
CAS No. 105628-07-7, 103745-39-7 (free base)
项目整合开发状态: Launched-1995
项目研究机构: Asahi Kasei (Originator), Schering AG (Licensee)
合成路线:5-Isoquinolinesulfonic acid (I) is heated at 85 C with SOCl2 and DMF yielding 5-isoquinolinesulfonyl chloride hydrochloride (II).The reaction of (II) with hexahydro-1H-1,4-diazepine affords hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine (III) in CH2Cl2.Finally,the reaction of (III) with HCl gives hexahydro-1-(5-isoquinolinesulfonyl)-1H-1,4-diazepine hydrochloride (IV).(scheme 10964901a)