Bunazosin hydrochloride, E-1015(retard), E-643, Andante, Detantol
盐酸布那唑嗪 布纳唑嗪 Chemical Name: 4-Amino-6,7-dimethoxy-2-[4-(n-butyryl)homopiperazin-1-yl]quinazoline hydrochloride
CAS No. 52712-76-2, 80755-51-7 (free base)
项目整合开发状态: Launched-1985
项目研究机构: Eisai (Originator), Boehringer Ingelheim (Licensee), Santen (Licensee)
合成路线:Compound can be prepared in two different ways:1) By condensation of 2-chloro-4-amino-5,7-dimethoxyquinazoline (I) with 1-(n-butyryl)homopiperazine (II) in refluxing butanol.2) By cyclization of 2-amino-4,5-dimethoxybenzonitrile (III) with 4-(n-butyryl)homopiperazin-1-formamidine (IV),by means of sodium methoxide in refluxing dimethylsulfoxide.
📌 参考资料/链接：
参考文献标题:E-643
文献作者:Castar,J.; Weetman,D.F.
参考来源:Drugs Fut 1978,3(8),582
📄 详细内容
合成路线:Compound can be prepared in two different ways:1) By condensation of 2-chloro-4-amino-5,7-dimethoxyquinazoline (I) with 1-(n-butyryl)homopiperazine (II) in refluxing butanol.2) By cyclization of 2-amino-4,5-dimethoxybenzonitrile (III) with 4-(n-butyryl)homopiperazin-1-formamidine (IV),by means of sodium methoxide in refluxing dimethylsulfoxide.
参考文献标题:
文献作者:Takahashi,T.; Sugimoto,H.
参考来源:JP 7682285
合成路线:Compound can be prepared in two different ways:1) By condensation of 2-chloro-4-amino-5,7-dimethoxyquinazoline (I) with 1-(n-butyryl)homopiperazine (II) in refluxing butanol.2) By cyclization of 2-amino-4,5-dimethoxybenzonitrile (III) with 4-(n-butyryl)homopiperazin-1-formamidine (IV),by means of sodium methoxide in refluxing dimethylsulfoxide.
参考文献标题:
文献作者:Takahashi,T.; Sugimoto,H.
参考来源:JP 75140474
产品链接: CAS No. 52712-76-2›› 产品链接: CAS No.80755-51-7››