新产品编号:46387

Chemical Name: cis-1,1-Dichloro-2-[4-[2-(1-piperidyl)ethoxy]phenyl]-3-phenylcyclopropane citrate
CAS No. 142513-50-6, 142513-44-8 (free base)
项目整合开发状态: Biological Testing
项目研究机构: University of Oklahoma Health Sci. Cent. (Originator)
合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线:By a two-phase catalytic cyclopropanation of 4,4'-dimethoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(dimethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(diethylamino)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线:By a two-phase catalytic cyclopropanation of 4-[2-(1-piperidinyl)ethoxy]-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.

合成路线:By a two-phase catalytic cyclopropanation of 4-methoxy-cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
📌 参考资料/链接:
参考文献标题:Synthesis and biological evaluation of a series of gem-dichlorocyclopropanes as antitumor agents
文献作者:Griffin,M.T.; et al.
参考来源:Anti-Cancer Drug Des 1992,7(1),49.

📄 详细内容


合成路线:By a two-phase catalytic cyclopropanation of cis-stilbene (I) with chloroform,conc.NaOH and triethbenzylammonium chloride (TEBA).Alternatively the cyclopropanation of (I) can also be performed with bromodichloromethyl(phenyl)mercury (A) in refluxing benzene.
参考文献标题:Synthesis and biological evaluation of a series of 1,1-dichloro-2,2,3-triaryl cyclopropanes as pure antiestrogens
文献作者:Day,B.W.; Magarian,R.A.; Jain,P.T.; Pento,J.T.; Mousissian,G.K.; Meyer,K.
参考来源:J Med Chem 1991,34(2),842-851.