Naproxen nitroxybutyl ester, Nitronaproxen, AZD-3582, ZD-3582, NO-naproxen, HCT-3012

Chemical Name: 2-(6-Methoxynaphthalen-2-yl)propionic acid 4-(nitrooxy)butyl ester
CAS No. 170591-17-0
项目整合开发状态: Phase II
项目研究机构: NicOx (Originator)
合成路线:The sodium salt (II),prepared from racemic naproxen (I),was alkylated with 1-bromo-4-chlorobutane (III) in DMF to produce the 4-chlorobutyl ester (IV).Chloride displacement in (IV) by silver nitrate in hot acetonitrile gave rise to the target nitrate ester.