R-755

Chemical Name: N-(2,6-Diethylphenyl)-N'-[3-(2-methylphenyl)-6,7-dihydro-5H-indeno[5,6-b]thiophen-2-yl]urea
CAS No. 159387-63-0
项目整合开发状态: Preclinical
项目研究机构: Nihon Nohyaku (Originator)
合成路线:The required benzothiophenecarboxylic acid precursor (IV) was prepared by Friedel-Crafts acylation of 5-(methylthio)indan (I) with 2-methylbenzoyl chloride (II) followed by condensation of the resulting mercapto ketone (III) with hot chloroacetic acid.Curtius rearrangement of carboxylic acid (IV) using diphenylphosphoryl azide produced isocyanate (V),which was subsequently condensed with 2,6-diethylaniline (VI) to yield the title urea.