IB-643, SPA-S-753

Chemical Name: 21-[3,6-Dideoxy-3-[2-(dimethylamino)acetamido]-beta-D-mannopyranosyloxy]-N-[2-(dimethylamino)ethyl]-15,19-epoxy-3,7,9,11,13,15,17,41-octahydroxy-36,38-dimethyl-43-[4-(methylamino)phenyl]-5,43-dioxo-22(E),24(E),26(E),28(E),30(E),32(E),34(E)-tritetracontaheptaeno-37-lactone diaspartate; 33-[3,6-Dideoxy-3-[2-(dimethylamino)acetamido]-beta-D-mannopyranosyloxy]-N-[2-(dimethylamino)ethyl]-1,3,5,7,9,13,37-heptahydroxy-17-[4-hydroxy-1-methyl-6-[4-(methylamino)phenyl]-6-oxohexyl]-18-methyl-11,15-dioxo-16,39-dioxabicyclo[33.3.1]nonatriaconta-19(E),21(E),23(E),25(E),27(E),29(E),31(E)-heptaene-36-carboxamide diaspartate
CAS No. 143563-20-6, 143483-67-4 (free base)
项目整合开发状态: Preclinical
项目研究机构: SPA (Originator), IntraBiotics (Licensee), Kaken (Licensee)
合成路线:By condensation of partricin A 2-(dimethylamino)ethylamide (I) with N,N-dimethylglycine (II) by means of triethylamine and diphenyl phosphoroazidate (DPAZ) in dimethylacetamide.