PNU-96988, U-96988

Chemical Name: 6-(1-Benzylpropyl)-4-hydroxy-3-(1-phenylpropyl)pyran-2-one
CAS No. 149394-65-0
项目整合开发状态: Phase I
项目研究机构: Pfizer (Originator)
合成路线:The condensation of 4-hydroxy-6-methyl-2H-pyran-2-one (I) with 1-phenyl-1-propanol (II) by means of TsOH in toluene gives 4-hydroxy-6-methyl-3-(1-phenyl-propyl)-2H-pyran-2-one (III),which is alkylated with benzyl bromide and LDA in THF yielding 4-hydroxy-6-(2-phenylethyl)-3-(1-phenylpropyl)-2H-pyran-2-one (V).Finally this compound is submitted to a new alkylation process with ethyl iodide and LDA in THF to afford the target compound.