TZA-2237

Chemical Name: 7alpha-Mercapto-17-oxa-17a-homoandrosta-1,4-diene-3,17a-dione
CAS No. 159822-03-4
项目整合开发状态: Preclinical
项目研究机构: Teikoku Hormone (Originator)
合成路线:Treatment of D-homo-17-oxaandrosta-1,4,6-triene-3,17a-dione (I) with refluxing thioacetic acid (II) yields either 7-alpha-(acetylthio) derivative (III) or 1alpha,7alpha-bis(acetylthio) derivative (IV).The desired product can then be obtained either by treatment of (III) with NaOH in THF or by reaction of (IV) with sodium methylate in methanol.