NNC-19-1228

Chemical Name: N-(Benzothiazol-6-yl)carbamic acid 3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]propyl ester
CAS No. 150396-84-2 (oxalate salt(1:1))
项目整合开发状态: Preclinical
项目研究机构: Novo Nordisk (Originator)
合成路线:Reaction of 6-aminobenzothiazole (I) with phosgene in refluxing tolene affords isocyanate (II).Alkylation of 6-fluoro-3-(4-piperidinyl)-1,2-bensisoxazole hydrochloride (III) with 3-bromopropanol (IV) in the presence of potassium carbonate in acetone gave alcohol (V).Finally,condensation of this alcohol (V) with isocyanate (II) in DMF at 100 C yielded the title carbamate.