MDL-101002

Chemical Name: 3,3-Dimethyl-3,4-dihydroisoquinoline N-oxide
CAS No. 148671-62-9
项目整合开发状态: Preclinical
项目研究机构: Aventis Pharma (Originator)
合成路线:Cyclization of N-formyl-alpha,alpha-dimethyl-b-phenethylamine (I) with phosphorous pentoxide in refluxing toluene led to isoquinoline (II),which was oxidized with 3-chloroperbenzoic acid (III) in dichloromethane at 0 C to give oxaziridine (IV).Finally,oxazirine (IV) was rearranged with sulfuric acid in aqueous methanol at room temperature to afford the target N-oxide.