FR-134043

Chemical Name: (1S,15S,18S,21Z,24S,27R,29S,34S,37R)-29-Benzyl-21-ethylidene-27-hydroxy-15-(isobutyramido)-34-isopropyl-31,37-dimethyl-5,6-bis(sulfooxy)-36-oxa-9,11,17,20,23,28,31,33-octaazatetracyclo[16.13.6.1(24,28).0(3,8)]octatriaconta-3,5,7-triene-10,16,19,22,30,32,35,38-octaone disodium salt
CAS No. 177079-46-8 (free acid)
项目整合开发状态: Preclinical
项目研究机构: Fujisawa (Originator)
合成路线:Compound (I),isolated from the cultures of Streptomyces resistomycificus,was sulfated with sulfur trioxide trimethylamine complex and then converted to the sodium salt.
📌 参考资料/链接:
参考文献标题:WS7622A mono- or di- sulfate,process for preparation thereof and use thereof
文献作者:Takase,S.; Hatanaka,H.; Ezaki,M.; Tsujii,E.; Okamoto,M.; Shigematsu,N.; Okuhara,M.(Fujisawa Pharmaceutical Co.,Ltd.)
参考来源:EP 0465895; US 5364624