S-9788
Chemical Name: 6-[4-[2,2-Bis(4-fluorophenyl)ethylamino]piperidin-1-yl]-N,N'-diallyl-1,3,5-triazine-2,4-diamine bismethanesulfonate
CAS No. 140945-01-3 (free base)
项目整合开发状态: Phase II
项目研究机构: Servier (Originator)
合成路线:The 1-[4,6-bis(allylamino)-1,3,5-triazin-2-yl]-4-piperidone hydrochloride (I) is added to [bis(4-fluorophenyl)methyl]amine (II) in dry methanol.The solution is acidified to pH 6 before adding NaBH3CN,resulting in 6-[4-[2,2-di-(4-fluorophenyl)ethylamino]piperidin-1-yl]-N,N'-diallyl-1,3,5-triazine-2,4-diamine (III).Treatment of (III) with methanesulfonic acid in isopropanol gives the bismethanesulfonate salt.
📌 参考资料/链接：
参考文献标题:New triazine derivatives as potent modulators of multidrug resistance
文献作者:Dhainaut,A.; R間nier,G.; Atassi,G.; Pierr? A.; L閛nce,S.; Kraus-Berthier,L.; Prost,J.F.
参考来源:J Med Chem 1992,35(13),2481-96
📄 详细内容
合成路线:The 1-[4,6-bis(allylamino)-1,3,5-triazin-2-yl]-4-piperidone hydrochloride (I) is added to [bis(4-fluorophenyl)methyl]amine (II) in dry methanol.The solution is acidified to pH 6 before adding NaBH3CN,resulting in 6-[4-[2,2-di-(4-fluorophenyl)ethylamino]piperidin-1-yl]-N,N'-diallyl-1,3,5-triazine-2,4-diamine (III).Treatment of (III) with methanesulfonic acid in isopropanol gives the bismethanesulfonate salt.
参考文献标题:S9788
文献作者:Mazier,B.; Berille,J.; Sarkany,M.; G閞ard,B.; Lucas,C.; Paraire,M.; Berlion,M.; Bizzari,J.P.; Giroux,B.
参考来源:Drugs Fut 1993,18(8),711
产品链接: CAS No. 140945-01-3››