Denzimol, Rec-151533
登齐醇Chemical Name: (?-1-[(4-Phenethyl)phenyl]-2-(N-imidazolyl)ethanol; (?-alpha-(p-Phenethylphenyl)imidazole-1-ethanol; (?-alpha-[4-(2-Phenylethyl)phenyl]-1H-imidazole-1-ethanol
CAS No. 73931-96-1
项目整合开发状态: Phase III
项目研究机构: Recordati (Originator)
合成路线:The condensation of imidazole (I) with 4-(phenethyl)phenacyl chloride (II) in DMF gives 1-[4-(phenethyl)phenacyl]imidazole (III),which is then reduced with NaBH4 in refluxing methanol.
📌 参考资料/链接：
参考文献标题:Imidazole derivs.
文献作者:Nardi,D.; Tajana,A.; Magistretti,M.J.(Recordati Industria Chimica e Farmaceutica SpA)
参考来源:DE 2929777
📄 详细内容
合成路线:The condensation of imidazole (I) with 4-(phenethyl)phenacyl chloride (II) in DMF gives 1-[4-(phenethyl)phenacyl]imidazole (III),which is then reduced with NaBH4 in refluxing methanol.
参考文献标题:Denzimol
文献作者:Castar,J.; Serradell,M.N.; Blancafort,P.; de Angelis,L.
参考来源:Drugs Fut 1983,8(11),915
合成路线:The condensation of imidazole (I) with 4-(phenethyl)phenacyl chloride (II) in DMF gives 1-[4-(phenethyl)phenacyl]imidazole (III),which is then reduced with NaBH4 in refluxing methanol.
参考文献标题:Synthesis and anticonvulsant avtivity of N-(benzoylalkyl)imidazoles and N-(omega-phenyl-omega-hydroxyalkyl)imidazoles
文献作者:Nardi,D.; Tajana,A.; Leonardi,A.; Pennini,R.; Portioli,F.; Magistretti,M.J.; Subissi,A.
参考来源:J Med Chem 1981,24(6),727-731
产品链接: CAS No. 73931-96-1››