合成路线:The condensation of 2-nitroimidazole (I) with N-(3-bromopropyl)phthalimide (II) by means of NaH in DMSO gives N-[3-(2-nitroimidazol-1-yl)propyl]phthalimide (III),which is treated with hydrazine in ethanol/water to yield 3-(2-nitroimidazol-1-yl)propylamine (IV).Finally this amine is condensed with 9-chloroacridine by means of TEA.
合成路线:The condensation of 2-nitroimidazole (I) with N-(2-bromoethyl)phthalimide (II) by means of NaH in DMSO gives N-[2-(2-nitroimidazol-1-yl)ethyl]phthalimide (III),which is treated with hydrazine in ethanol/water to yield 2-(2-nitroimidazol-1-yl)ethylamine (IV).Finally this amine is condensed with 9-chloroacridine by means of TEA.
参考文献标题:Studies on antiprotozoans.Synthesis and biological activity of some styrylimidazole derivatives
文献作者:DeCarneri,I.; Giraldi,P.N.; Mariotti,V.
参考来源:J Med Chem 1968,1160-70
合成路线:The condensation of 2-nitroimidazole (I) with N-(3-bromopropyl)phthalimide (II) by means of NaH in DMSO gives N-[3-(2-nitroimidazol-1-yl)propyl]phthalimide (III),which is treated with hydrazine in ethanol/water to yield 3-(2-nitroimidazol-1-yl)propylamine (IV).Finally this amine is condensed with 9-chloroacridine by means of TEA.
合成路线:The condensation of 2-nitroimidazole (I) with N-(2-bromoethyl)phthalimide (II) by means of NaH in DMSO gives N-[2-(2-nitroimidazol-1-yl)ethyl]phthalimide (III),which is treated with hydrazine in ethanol/water to yield 2-(2-nitroimidazol-1-yl)ethylamine (IV).Finally this amine is condensed with 9-chloroacridine by means of TEA.
参考文献标题:Nitroheterocyclic-linked acridines as DNA-targeting bioreductive agents
文献作者:Bloomer,W.D.; Papadopoulou,M.V.
参考来源:Drugs Fut 1993,18(3),231
产品链接: CAS No. 140448-36-8››