LU-29-066

Chemical Name: 3-(4-Fluorophenyl)-2,5-dimethyl)-1-[1-[2-(2-oxoimidazolidin-1-yl)ethyl]piperidin-4-yl]-1H-indole
CAS No. 141307-07-5
项目整合开发状态: Biological Testing
项目研究机构: Lundbeck (Originator)
合成路线:Piperidinoindole (I) was alkylated with chloroacetonitrile in the presence of Et3N in N-methylpyrrolidinone to afford nitrile (II),which was reduced to primary amine (III) by means of LiAlH4 and AlCl3.A further alkylation-reduction sequence over (III) provided in turn nitrile (IV) and then amine (V).Finally,condensation with phosgene yielded the target imidazolidinone (1).