BF-388

Chemical Name: 1-(3,5-Di-tert-butyl-4-hydroxyphenyl)pyrrolidin-2-one
CAS No. 129464-78-4
项目整合开发状态: Preclinical
项目研究机构: Biofor (Originator)
合成路线:The 2,6-di-tert-butylphenol (I) was nitrated with nitric acid,followed by reduction with hydrogen using a platinum catalyst to afford 4-amino-2,6-di-tert-butylphenol (II).The reaction of (II) with 4-chlorobutyryl chloride (III) gave the intermediate 4-chlorobutyramide (IV),which on treatment with sodium hydride underwent cyclization to afford 1-(3,5-di-tert-butyl-4-hydroxyphenyl)pyrrolidin-2-one,BF-388.