MCDF

Chemical Name: 1,3,8-Trichloro-6-methyldibenzofuran
CAS No. 118174-38-2
项目整合开发状态: Preclinical
项目研究机构: University of Texas System (Originator)
合成路线:4-Chloro-2-methylphenol (I) is condensed with 2,4,6-trichloroaniline (II) by heating to 120-140 C with amyl nitrite for 18 hours.The excess phenol is removed in vacuo; the residue is adsorbed on silica gel,applied to the top of a silica gel column and the crude phenolic fraction isolated by elution with hexane/acetone (95:5).The phenolic fraction,which contains 2-methyl-2'4,4',6-tetrachlorobiphenylol (III) and other isomers,is dissolved in dimethyl sulfoxide,anhydrous sodium carbonate is added,and the mixture is then heated with stirring at 160 C for 2 hours.The cyclization product,1,3,8-trichloro-6-methyldibenzofuran (MCDF) is isolated by column chromatography and further purified by crystallization from methanol or methanol/anisole.