Ibrolipim, OPF-009, NO-1886
Chemical Name: N-(4-Bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide; 4-[N-(4-Bromo-2-cyanophenyl)carbamoyl]benzylphosphonic acid diethyl ester
CAS No. 133208-93-2
项目整合开发状态: Phase II
项目研究机构: Otsuka (Originator), TAP (Licensee)
合成路线:By condensation of 4-(chloroformyl)benzylphosphonic acid diethyl ester (I) with 2-amino-5-bromobenzonitrile (II) by means of dimethylaminopyridine (DMAP) and triethylamine in dichloromethane.
📌 参考资料/链接：
参考文献标题:Carboxamide derivs
文献作者:Tsutsumi,K.; Uesaka,E.; Shinomiya,K.; Tsuda,Y.; Shoji,Y.; Shima,A.(Otsuka Pharmaceutical Co.,Ltd.)
参考来源:AU 9056011; EP 0402033; JP 1991068592
📄 详细内容
合成路线:By condensation of 4-(chloroformyl)benzylphosphonic acid diethyl ester (I) with 2-amino-5-bromobenzonitrile (II) by means of dimethylaminopyridine (DMAP) and triethylamine in dichloromethane.
参考文献标题:NO-1886
文献作者:Tracy,M.; Castar,J.
参考来源:Drugs Fut 1996,21(9),901
产品链接: CAS No. 133208-93-2››