RP-66681

Chemical Name: (+)-N-[3-[alpha-[(Z)-1-Methyl-4-piperidinyloxyimino]benzyl]phenyl]-3alpha-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carboxamide
CAS No. 132710-24-8
项目整合开发状态: Preclinical
项目研究机构: Aventis Pharma (Originator)
合成路线:This compound has been obtained by two similar ways:1.By condensation of the benzophenone derivative (I) with O-(1-methylpiperidin-4-yl)hydroxylamine by means of K2CO3 in propanol.2.The reaction of benzophenone derivative (I) with hydroxylamine by means of K2CO3 in propanol gives the corresponding oxime (III),which is finally alkylated with 4-chloro-1-methylpiperidine (IV) by means of NaH in DMF.