FG-5803
Chemical Name: N-Cyclohexyl-4-[4-(4-fluorophenyl)-4-oxobutyl]-1-piperazinecarboxamide hydrochloride
CAS No. 97507-92-1
项目整合开发状态: Preclinical
项目研究机构: Pfizer (Originator)
合成路线:FG5803 is obtained in a three-step synthesis:In the first step 4-(4-fluorophenyl)-4,4-ethylenedioxybutylchloride (A) reacts with piperazine (B) to give 1-[4-(4-fluorophenyl)-4,4-ethylenedioxybutyl]piperazine (I),which is reacted with cyclohexylisocyanate (C) to form 4-[4-(4-fluorophenyl)-4,4-ethylenedioxybutyl]-N-cyclohexyl-1-piperazinecarboxamide (II).The protecting group is removed by HCl in ethanol and the final product is isolated,4-[4-(4-fluorophenyl)-4-oxobutyl]-N-cyclohexyl-1-piperazinecarboxamide hydrochloride (III).
📌 参考资料/链接：
参考文献标题:Novel 1-piperazinecarboxamide derivs.
文献作者:Bjork,A.; Fex,T.; Olsson,K.; Abramo,A.; Gustafsson,B.; Christensson,E.(Ferrosan AB)
参考来源:EP 0136274; ES 8704917; ES 8705411; ES 8802039; JP 1985501956; US 4935419; WO 8500811
📄 详细内容
合成路线:FG5803 is obtained in a three-step synthesis:In the first step 4-(4-fluorophenyl)-4,4-ethylenedioxybutylchloride (A) reacts with piperazine (B) to give 1-[4-(4-fluorophenyl)-4,4-ethylenedioxybutyl]piperazine (I),which is reacted with cyclohexylisocyanate (C) to form 4-[4-(4-fluorophenyl)-4,4-ethylenedioxybutyl]-N-cyclohexyl-1-piperazinecarboxamide (II).The protecting group is removed by HCl in ethanol and the final product is isolated,4-[4-(4-fluorophenyl)-4-oxobutyl]-N-cyclohexyl-1-piperazinecarboxamide hydrochloride (III).
参考文献标题:FG5803
文献作者:Lundstedt,T.; Bjk,A.; Pettersson,G.; Svartengren,J.; Christensson,E.; Gustavsson,B.
参考来源:Drugs Fut 1990,15(12),1176