合成路线:Sodium borohydride reduction of succinimide in isopropanol,according to the Speckamp's procedure,gives 5-isopropoxy-2-pyrrolidinone.Condensation with 3-trifluoromethylbenzenesulfonyl chloride (2) is effected with n-butyllithium in tetrahydrofuran at low temperature to give RU-47067 in an overall yield of 38%.
参考文献标题:NaBH4 reduction of cyclic imides
文献作者:Wijnberg,J.B.P.A.; Speckamp,W.N.; ubert,J.C.
参考来源:Tetrahedron 1975,311437-41
合成路线:Sodium borohydride reduction of succinimide in isopropanol,according to the Speckamp's procedure,gives 5-isopropoxy-2-pyrrolidinone.Condensation with 3-trifluoromethylbenzenesulfonyl chloride (2) is effected with n-butyllithium in tetrahydrofuran at low temperature to give RU-47067 in an overall yield of 38%.
参考文献标题:m-Trifluoromethylbenzenesulfonyl chloride
文献作者:Hoffmann,R.V.
参考来源:Org Synth Coll7508-11
产品链接: CAS No. 111711-92-3››