Disodium cromproxate, 78012
Chemical Name: 7,7'-[(2-Hydroxytrimethylene)dioxy]bis(4-oxo-4H-1-benzopyran-2-carboxylic acid) disodium salt; 7,7'-[(2-Hydroxy-1,3-propanediyl)bis-(oxy)]bis[4-oxo-4H-1-benzopyran-2-carboxylic acid] disodium salt; 1,3-Bis(2-carboxychromon-7-yloxy)-2-hydroxypropane disodium salt
CAS No. 37092-38-9
项目整合开发状态: Clinical
项目研究机构: AstraZeneca (Originator), Institute of Materia Medica (Originator)
合成路线:2,4-Dihydroxyacetophenone (I) is formed by the Friedel-Crafts acetylation of resorcinol.This compound is condensed with diethyl oxalate in sodium ethoxide solution,affording (II).Disodium cromproxate (IV) is conveniently prepared from (II) by treatment with epichlorohydrine in aqueous ethanolic alkaline solution.It is recrystallized from hot water.
📌 参考资料/链接：
参考文献标题:A simplified synthesis of 1,3-bis-(2-carboxychromone-7-oxy)-2-hydroxypropane disodium salt (78012)
文献作者:Liang,X.; Qi,J.; Lu,Y.
参考来源:Acta Pharm Sin 1982,17(2),143-5
📄 详细内容
合成路线:2,4-Dihydroxyacetophenone (I) is formed by the Friedel-Crafts acetylation of resorcinol.This compound is condensed with diethyl oxalate in sodium ethoxide solution,affording (II).Disodium cromproxate (IV) is conveniently prepared from (II) by treatment with epichlorohydrine in aqueous ethanolic alkaline solution.It is recrystallized from hot water.
参考文献标题:Disodium Cromproxate
文献作者:Ruyun,J.
参考来源:Drugs Fut 1991,16(5),422
产品链接: CAS No. 37092-38-9››