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项目整合精选>>>Doxazosin mesylate, UK-33274, Dedralen, Carduran Neo, Zoxan, Progandol, Tensiobas, Cardenalin, Cardular, Cardura, Carduran
Doxazosin mesylate, UK-33274, Dedralen, Carduran Neo, Zoxan, Progandol, Tensiobas, Cardenalin, Cardular, Cardura, Carduran
甲磺酸多沙唑嗪 多沙唑嗪 盐酸多沙唑嗪Chemical Name: 4-Amino-2-[4-(1,4-benzodioxan-2-ylcarbonyl)piperazin-1-yl]-6,7-dimethoxyquinazoline methanesulfonate; 1-(4-Amino-6,7-dimethoxyquinazolin-2-yl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine methanesulfonate
CAS No. 77883-43-3, 74191-85-8 (free base), 70918-01-3 (monoHCl)
项目整合开发状态: Launched-1988
项目研究机构: Pfizer (Originator), Almirall Prodesfarma (Licensee), Italfarmaco (Licensee), Andrx (Distributor)
合成路线:The acylation of piperazine (I) with 1,4-benzodioxan-2-ylcarbonyl chloride (II) by means of sodium acetate in water-acetone gives N-(1,4-benzodioxan-2-carbonyl)piperazine (III),which is then condensed with 4-amino-2-chloro-6,7-dimethoxyquinazoline (IV) in refluxing butanol.
📌 参考资料/链接：
参考文献标题:Antihypertensive 4-amino-2-[4-(1,4-benzodioxan-2-carbonyl) piperazin-1-yl or homopiperazin-1-yl]quinazolines
文献作者:Campbell,S.F.(Pfizer Inc.)
参考来源:DE 2847623; FR 24079529; US 4188390
📄 详细内容
合成路线:The acylation of piperazine (I) with 1,4-benzodioxan-2-ylcarbonyl chloride (II) by means of sodium acetate in water-acetone gives N-(1,4-benzodioxan-2-carbonyl)piperazine (III),which is then condensed with 4-amino-2-chloro-6,7-dimethoxyquinazoline (IV) in refluxing butanol.
参考文献标题:Doxazosin
文献作者:Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1982,7(12),877