Amezinium methylsulfate, LU-1631, Risumic, Supratonin, Regulton
甲磺美嗪Chemical Name: 4-Amino-6-methoxy-1-phenylpyridazinium methylsulfate
CAS No. 30578-37-1, 51410-15-2 (chloride)
项目整合开发状态: Launched-1981
项目研究机构: Abbott (Originator), Dainippon Pharmaceutical (Licensee), Gr黱enthal (Licensee)
合成路线:4-Chloro-5-amino-2-phenyl-3(2H)-pyridazinone (I) is treated with Pd/C/NaBH4 to give 5-amino-2-phenyl-3(2H)-pyridazinone (II),which is O-methylated with dimethylsultate to LU-1631.
📌 参考资料/链接：
参考文献标题:Amezinium metilsulfate
文献作者:Unterhalt,B.
参考来源:Drugs Fut 1981,6(4),207
📄 详细内容
合成路线:4-Chloro-5-amino-2-phenyl-3(2H)-pyridazinone (I) is treated with Pd/C/NaBH4 to give 5-amino-2-phenyl-3(2H)-pyridazinone (II),which is O-methylated with dimethylsultate to LU-1631.
参考文献标题:Synth鑣e de d閞iv閟 hydrazino et hydrazones dans la s閞ie des thiazolo[4,5-d]pyridazinones-7
文献作者:Beljean,M.; et al.
参考来源:Bull Soc Chim France 1973,3324
产品链接: CAS No. 30578-37-1››