Norfloxacin succinil, Eminor
琥诺沙星Chemical Name: 7-[4-(3-Carboxypropionyl)piperazin-1-yl]-1-ethyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
CAS No. 100587-52-8, 100587-53-9 (diNa salt)
项目整合开发状态: Launched-1984
项目研究机构: Farmades (Originator)
合成路线:By acylation of 1-ethyl-6-fluoro-4-oxo-7-piperazine-1,4-dihydroquinoline-3-carboxylic acid (I) with succinic anhydride (II) in refluxing dichloromethane.Acetic acid can also be used as solvent in the acylation.
📌 参考资料/链接：
参考文献标题:Cpds.having antibacterial activity,process for their preparation and pharmaceutical compsns.Containing them
文献作者:Di Schiena,M.(Farmades)
参考来源:EP 0155006
📄 详细内容
合成路线:By acylation of 1-ethyl-6-fluoro-4-oxo-7-piperazine-1,4-dihydroquinoline-3-carboxylic acid (I) with succinic anhydride (II) in refluxing dichloromethane.Acetic acid can also be used as solvent in the acylation.
参考文献标题:NORFLOXACIN SUCCINIL
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1990,15(6),578
产品链接: CAS No. 100587-52-8››