LY-255262

合成路线:The reaction of N-(tert-butoxycarbonyl)-L-serine methyl ester (I) with hydrazine gives the corresponding hydrazide (II),which is acylated with trifluorothioacetic acid S-ethyl ester (III),yielding the diacylated hydrazine (IV).The cyclization of (IV) by means of DEAD and PPh3 affords the pyrazolidinone (V),which is deacylated with NaOH to furnish 4(S)-(tert-butoxycarbonyl)pyrazolidin-3-one (VI).The condensation of (VI) with vinylphosphonate (VII) gives the adduct (VIII),which is cyclized with the oxalyl monoester chloride (IX) by means of DIEA,yielding the pyrazolopyrazole (X).Finally,this compound is deprotected in acid medium and acylated with thiazole derivative (XI) by means of a Pd(0) catalyst to furnish the target compound.

合成路线:The reaction of N-(tert-butoxycarbonyl)-L-serine methyl ester (I) with hydrazine gives the corresponding hydrazide (II),which is acylated with trifluorothioacetic acid S-ethyl ester (III),yielding the diacylated hydrazine (IV).The cyclization of (IV) by means of DEAD and PPh3 affords the pyrazolidinone (V),which is deacylated with NaOH to furnish 4(S)-(tert-butoxycarbonyl)pyrazolidin-3-one (VI).The condensation of (VI) with vinylphosphonate (VII) gives the adduct (VIII),which is cyclized with the oxalyl monoester chloride (IX) by means of DIEA,yielding the pyrazolopyrazole (X).Finally,this compound is deprotected in acid medium and acylated with thiazole derivative (XI) by means of a Pd(0) catalyst to furnish the target compound.

合成路线:The cyclization of N-(tert-butoxycarbonyl)-O-(p-toluenesulfonyl)serine (I) with hydrazine gives the pyrazolidinone (II),which by reaction with formaldehyde yields the ylide (III).The cyclization of (III) with the vinyl sulfone (IV) by means of NMM affords the bicyclic pyrazolidinone (V),which is deprotected in acid medium,then condensed with the acid chloride (VI) and treated with a Pd(0) catalyst.

参考文献标题:BICYCLIC PYRAZOLIDINONE ANTIBACTERIAL AGENTS
文献作者:Jungheim,L.N.; Ternansky,R.J.; Holmes,R.E.
参考来源:Drugs Fut 1990,15(2),149


合成路线:The reaction of N-(tert-butoxycarbonyl)-L-serine methyl ester (I) with hydrazine gives the corresponding hydrazide (II),which is acylated with trifluorothioacetic acid S-ethyl ester (III),yielding the diacylated hydrazine (IV).The cyclization of (IV) by means of DEAD and PPh3 affords the pyrazolidinone (V),which is deacylated with NaOH to furnish 4(S)-(tert-butoxycarbonyl)pyrazolidin-3-one (VI).The condensation of (VI) with vinylphosphonate (VII) gives the adduct (VIII),which is cyclized with the oxalyl monoester chloride (IX) by means of DIEA,yielding the pyrazolopyrazole (X).Finally,this compound is deprotected in acid medium and acylated with thiazole derivative (XI) by means of a Pd(0) catalyst to furnish the target compound.

合成路线:The reaction of N-(tert-butoxycarbonyl)-L-serine methyl ester (I) with hydrazine gives the corresponding hydrazide (II),which is acylated with trifluorothioacetic acid S-ethyl ester (III),yielding the diacylated hydrazine (IV).The cyclization of (IV) by means of DEAD and PPh3 affords the pyrazolidinone (V),which is deacylated with NaOH to furnish 4(S)-(tert-butoxycarbonyl)pyrazolidin-3-one (VI).The condensation of (VI) with vinylphosphonate (VII) gives the adduct (VIII),which is cyclized with the oxalyl monoester chloride (IX) by means of DIEA,yielding the pyrazolopyrazole (X).Finally,this compound is deprotected in acid medium and acylated with thiazole derivative (XI) by means of a Pd(0) catalyst to furnish the target compound.
参考文献标题:The synthesis of bicyclic pyrazolidinone antibacterial agents
文献作者:Ternansky,R.J.; Draheim,S.E.
参考来源:30th Nat Org Symp (Vancouver) 1987,