ST-587
Chemical Name: 2-(2-Chloro-5-trifluoromethylanilino)-2-imidazoline
CAS No. 15327-37-4
项目整合开发状态: Preclinical
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:The reaction of 2-chloro-5-tritluoromethylaniline (I) with ammonium thiocyanate (II) in hot chlorobenzene gives N-(2-chloro-5-trifluoromethylphenyl)isothiourea (III),whith is cyclized with ethylenediamine (IV) in refluxing methanol.
📌 参考资料/链接：
参考文献标题:Derivs.of 2-(2'-halo-anilino)1,3-diazacyclo-pentene-(2)
文献作者:Stahle,H.; Zeiler,K.; Koppe,H.; Wolf,M.; Hoefke,W.(Boehringer Ingelheim GmbH)
参考来源:US 3462433
📄 详细内容
合成路线:The reaction of 2-chloro-5-tritluoromethylaniline (I) with ammonium thiocyanate (II) in hot chlorobenzene gives N-(2-chloro-5-trifluoromethylphenyl)isothiourea (III),whith is cyclized with ethylenediamine (IV) in refluxing methanol.
参考文献标题:ST-587
文献作者:Weetman,D.F.; Serradell,M.N.; Castar,J.; Blancafort,P.
参考来源:Drugs Fut 1982,7(9),653