Merbarone, MB, NSC-336628
Chemical Name: 5-(N-phenylcarboxamido)-2-thiobarbituric acid; 6-Hydroxy-4-oxo-N-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CAS No. 97534-21-9
项目整合开发状态: Phase II
项目研究机构: National Cancer Institute (Originator), Uniroyal (Originator)
合成路线:Merbarone can be prepared in 64% yield by stirring a mixture of 2-thiobarbituric acid (I) and phenyl isocyanate (II) for 4 h at 75-85 C in pyridine.
📌 参考资料/链接：
参考文献标题:Pyrimidine-5-carboxamide or thiocarboxamide derivs
文献作者:Brewer,A.D.; Minatelli,J.A.(Uniroyal Chemical Company,Inc.)
参考来源:BE 0901301; CH 671225; DE 3446371; ES 8606296; FR 2557108; GB 2152047; JP 1985166669; JP 1987174058
📄 详细内容
合成路线:Merbarone can be prepared in 64% yield by stirring a mixture of 2-thiobarbituric acid (I) and phenyl isocyanate (II) for 4 h at 75-85 C in pyridine.
参考文献标题:Merbarone
文献作者:Zee-Cheng,R.K.-Y.; Cheng,C.C.
参考来源:Drugs Fut 1987,12(3),217
产品链接: CAS No. 97534-21-9››