Benzquinamide, NSC-224070, BZQ, Emete-Con
Chemical Name: 2,5-Diaziridinyl-3,6-bis(2-hydroxyethylamino)-1,4-benzoquinone
CAS No. 59886-54-3
项目整合开发状态: Phase I
项目研究机构: Institute of Cancer Research (Originator)
合成路线:Ethyleneimine is reacted with tetrafluoro-1.4-benzoquinone (I) in the cold to form 2,5-diaziridinyl-3,6-difluoro-1-4-benzoquinone (II).The reaction with ethanolamine at room temperature results in BZQ,which is recrystallized from ethanol.
📌 参考资料/链接：
参考文献标题:BZQ
文献作者:Bosanquet,A.G.
参考来源:Drugs Fut 1986,11(1),12
📄 详细内容
合成路线:Ethyleneimine is reacted with tetrafluoro-1.4-benzoquinone (I) in the cold to form 2,5-diaziridinyl-3,6-difluoro-1-4-benzoquinone (II).The reaction with ethanolamine at room temperature results in BZQ,which is recrystallized from ethanol.
参考文献标题:Potential central nervous system antitumor agents.Aziridinylbenzoquinones
文献作者:Chou,F.; Khan,A.H.; Driscoll,J.S.
参考来源:J Med Chem 1976,19(11),1302
产品链接: CAS No. 59886-54-3››