IDPH-8032
Chemical Name: 6,8-Dinitro-2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzoxazin-1-one
CAS No. 96753-85-4
项目整合开发状态: Preclinical
项目研究机构: Indian Drugs (Originator)
合成路线:The reaction of 6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione (I) with ethyl carbazate (II) in refluxing ethanol gives 6,8-dinitro-3-(2-ethoxy-carbonyl)hydrazino-2H-1,4-benzoxazine (III),which undergoes ring closure in refluxing o-dichlorobenzene to give the title compound.
合成路线:The cyclocondensation of 2H-1,4 benzoxazine-3(4H)-thione (IV) with ethyl carbazate (II) in refluxing DMF gives 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzoxazin-1-one (V),which is nitrated at room temperature with a mixture of concentrated HNO3 and H2SO4.
📌 参考资料/链接：
参考文献标题:IDPH-8032
文献作者:Shridhar,D.R.; Arya,V.P.
参考来源:Drugs Fut 1985,10(7),559
📄 详细内容
合成路线:The reaction of 6,8-dinitro-2H-1,4-benzoxazine-3(4H)-thione (I) with ethyl carbazate (II) in refluxing ethanol gives 6,8-dinitro-3-(2-ethoxy-carbonyl)hydrazino-2H-1,4-benzoxazine (III),which undergoes ring closure in refluxing o-dichlorobenzene to give the title compound.
合成路线:The cyclocondensation of 2H-1,4 benzoxazine-3(4H)-thione (IV) with ethyl carbazate (II) in refluxing DMF gives 2,4-dihydro[1,2,4]triazolo[3,4-c][1,4]benzoxazin-1-one (V),which is nitrated at room temperature with a mixture of concentrated HNO3 and H2SO4.
参考文献标题:Potential diuretics.Part I.Synthesis of some substituted 2,4-dihydro-1-oxo/thioxo-1,2,4-triazolo[3,4-c][1,4]benzoxazines - Novel diuretic agents
文献作者:Shridhar,D.R.
参考来源:Indian J Chem 1984,2381279
产品链接: CAS No. 96753-85-4››