Zifrosilone, MDL-73745
齐罗硅酮Chemical Name: alpha,alpha,alpha-Trifluoro-3-(trimethylsilyl)acetophenone; 2,2,2-Trifluoro-1-[3-(trimethylsilyl)phenyl]ethanone
CAS No. 132236-18-1
项目整合开发状态: Phase II
项目研究机构: Aventis Pharma (Originator)
合成路线:The reaction of 1,3-dibromobenzene (I) with trimethylsilyl chloride (II) by means of Mg in ethyl ether gives 3-(trimethylsilyl)bromobenzene (III),which is then condensed with ethyl trifluoroacetate (IV) by means of butyllithium in ethyl ether - hexane.
📌 参考资料/链接：
参考文献标题:Novel acetylcholinesterase inhibitors
文献作者:Schirlin,D.; Collard,J.-N.; Hornsperger,J.-M.(Merrell Pharmaceuticals,Inc.)
参考来源:EP 0403713; EP 0409676; JP 1991038591; US 5693668
📄 详细内容
合成路线:The reaction of 1,3-dibromobenzene (I) with trimethylsilyl chloride (II) by means of Mg in ethyl ether gives 3-(trimethylsilyl)bromobenzene (III),which is then condensed with ethyl trifluoroacetate (IV) by means of butyllithium in ethyl ether - hexane.
参考文献标题:Subreum
文献作者:Prous,J.; Graul,A.; Castar,J.
参考来源:Drugs Fut 1994,19(9),845
产品链接: CAS No. 132236-18-1››