合成路线:Treatment of 3-(methylsulfanyl)aniline (I) with cyanogen bromide affords the cyanamide (II),which is further N-alkylated with iodomethane and NaH to afford (III).Subsequent condensation of cyanamide (III) with 2-chloro-5-(methylsulfanyl)aniline hydrochloride (IV) in refluxing chlorobenzene gives rise to the desired guanidine derivative.
参考文献标题:Synthesis and pharmacological evaluation of N-(2,5-disubstituted phenyl)-N'-(3-substituted phenyl)-N'-methylguanidines as N-methyl-D-aspartate receptor ion-channel blockers
文献作者:Hu,L.-Y.; Guo,J.; Magar,S.S.; Fischer,J.B.; Burke-Howie,K.J.; Durant,G.J.
参考来源:J Med Chem 1997,40(26),4281
合成路线:The methylation of N-[3-(methylsulfanyl)phenyl]cyanamide (I) with C3H3-I and NaH in THF gives the methylated cyanamide (II),which is then condensed with 2-chloro-5-(methylsulfanyl)aniline (III) in refluxing chlorobenzene to afford the target labeled guanidine.
参考文献标题:Synthesis of N-(2-chloro-5-methylthiophenyl)-N'-(3-methyl-thiophenyl)-N'-[3H3]methylguanidine,([3H3]CNS-5161)
文献作者:Gibbs,A.R.; et al.
参考来源:J.Label.Comp.and Radiopharm.2002,45(5),395
合成路线:Treatment of 3-(methylsulfanyl)aniline (I) with cyanogen bromide affords the cyanamide (II),which is further N-alkylated with iodomethane and NaH to afford (III).Subsequent condensation of cyanamide (III) with 2-chloro-5-(methylsulfanyl)aniline hydrochloride (IV) in refluxing chlorobenzene gives rise to the desired guanidine derivative.
参考文献标题:Synthesis and in vitro evaluation of N,N'-diphenyl and N-naphthyl-N'-phenylguanidines as N-methyl-D-aspartate receptor ion-channel ligands
文献作者:Dumont,F.; Sultana,A.; Waterhouse,R.N.
参考来源:Bioorg Med Chem Lett 2002,12(12),1583
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