Terbogrel, BIBV-308-SE, BIBV-308

特波格雷Chemical Name: 6-[3-(3-tert-Butyl-2-cyanoguanidino)phenyl]-6-(3-pyridyl)-5(E)-hexenoic acid
CAS No. 149979-74-8
项目整合开发状态: Phase II
项目研究机构: Boehringer Ingelheim (Originator)
合成路线:The reaction of (E)-6-(3-aminophenyl)-6-(3-pyridyl)-5-hexenoic acid methyl ester (I) with diphenyl N-cyanocarbinimidate (II) in isopropanol gives the N-cyanoisourea (III),which is condensed with tert-butylamine (IV) in refluxing isopropanol yielding the guanidine derivative (IV).Finally,hydrolysis of the ester group of (IV) with NaOH affords the target compound.