Terflavoxate hydrochloride, ND-907, REC-15/2053
特拉伏沙 Chemical Name: 3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 1,1-dimethyl-2-(1-piperidinyl)ethyl ester hydrochloride; 3-Methylflavone-8-carboxylic acid 1,1-dimethyl-2-(1-piperidinyl)ethyl ester hydrochloride
CAS No. 86433-39-8, 86433-40-1 (free base)
项目整合开发状态: Phase II
项目研究机构: Recordati (Originator)
合成路线:The chlorination of 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylic acid (I) with thionyl chloride gives the corresponding chloride (II),which is esterified with 1,1-dimethyl-2-(1-piperidinyl)ethanol (IV),obtained by alkylation of excess piperidine (III) with 1-chloro-2-methyl-2-propanol.Rec 15/2053 is obtained as the hydrochloride.
📌 参考资料/链接：
参考文献标题: 3-Methylflavone-8-carboxylic acid esters
文献作者:Nardi,D.; Tajana,A.; Cazzulati,P.; Graziani,G.; Pennini,R.; Casadio,S.(Recordati Industria Chimica e Farmaceutica SpA)
参考来源:EP 0072620; GB 2104507
📄 详细内容
合成路线:The chlorination of 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylic acid (I) with thionyl chloride gives the corresponding chloride (II),which is esterified with 1,1-dimethyl-2-(1-piperidinyl)ethanol (IV),obtained by alkylation of excess piperidine (III) with 1-chloro-2-methyl-2-propanol.Rec 15/2053 is obtained as the hydrochloride.
参考文献标题:Terflavoxate Hydrochloride
文献作者:Testa,R.; Leonardi,A.; Tajana,A.
参考来源:Drugs Fut 1994,19(3),248
合成路线:The chlorination of 2-phenyl-3-methyl-4-oxo-4H-1-benzopyran-8-carboxylic acid (I) with thionyl chloride gives the corresponding chloride (II),which is esterified with 1,1-dimethyl-2-(1-piperidinyl)ethanol (IV),obtained by alkylation of excess piperidine (III) with 1-chloro-2-methyl-2-propanol.Rec 15/2053 is obtained as the hydrochloride.
参考文献标题:Urinary incontinence in the elderly.Physiology,pathophysiology,diagnosis and treatment
文献作者:Williams,M.E.; Pannil,C.
参考来源:Ann Intern Med 1982,97(6),895-907
产品链接: CAS No. 86433-39-8›› 产品链接: CAS No.86433-40-1››