Terbufibrol, K-11267
特丁贝罗Chemical Name: 4-[3-(4-tert-Butylphenoxy)-2-hydroxypropoxy]benzoic acid
CAS No. 56488-59-6
项目整合开发状态: Not Determined
项目研究机构:
合成路线:Terbufibrol can be obtained in two different ways:1) Condensation of 4-tert-butylphenol (I) with epichlorohydrin (II) by means of NaOH in methanol gives 1,2-epoxy-3-(4'-tert-butylphenoxy)propane (III) which is condensed with methyl 4-hydroxybenzoate (IV) in the presence of a catalytic amount of a base yielding the methyl ester (V) which is then hydrolyzed with NaOH and finally acidified to yield terbufibrol.2) Condensation of methyl 4-hydroxybenzoate (IV) with epichlorohydrin (II) by means of NaOH in methanol gives 1,2-epoxy-3-(4'-methoxycarbonylphenoxy)propane (VI) which is condensed with 4-tert-butylphenol (I) in the presence of a catalytic amount of a base yielding the methyl ester (V) which is then hydrolyzed with NaOH and finally acidified to yield terbufibrol.
📌 参考资料/链接：
参考文献标题:
文献作者:Grill,H.; et al.
参考来源:DE 24460689
📄 详细内容
合成路线:Terbufibrol can be obtained in two different ways:1) Condensation of 4-tert-butylphenol (I) with epichlorohydrin (II) by means of NaOH in methanol gives 1,2-epoxy-3-(4'-tert-butylphenoxy)propane (III) which is condensed with methyl 4-hydroxybenzoate (IV) in the presence of a catalytic amount of a base yielding the methyl ester (V) which is then hydrolyzed with NaOH and finally acidified to yield terbufibrol.2) Condensation of methyl 4-hydroxybenzoate (IV) with epichlorohydrin (II) by means of NaOH in methanol gives 1,2-epoxy-3-(4'-methoxycarbonylphenoxy)propane (VI) which is condensed with 4-tert-butylphenol (I) in the presence of a catalytic amount of a base yielding the methyl ester (V) which is then hydrolyzed with NaOH and finally acidified to yield terbufibrol.
参考文献标题:Terbufibrol
文献作者:Janiak,P.St.
参考来源:Drugs Fut 1979,4(2),140
产品链接: CAS No. 56488-59-6››