Methylnaltrexone bromide, MRZ-2663BR

溴甲纳曲酮 甲基纳曲酮 Chemical Name: 17-(Cyclopropylmethyl)-4,5alpha-epoxy-3,14-dihydroxy-17-methyl-6-oxomorphinanium bromide; N-Methylnaltrexone bromide
CAS No. 73232-52-7, 83387-25-1 (cation), 73232-53-8 (iodide), 125292-47-9 (racemate)
项目整合开发状态: Phase III
项目研究机构: Mallinckrodt (Supplier), University of Chicago (Originator), Progenics (Licensee)
合成路线:By quaternization of N-(cyclopropylmethyl)noroxymorphone (I) with methyl bromide in acetone/DMF.