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项目整合精选>>>Leurubicin, E-88/032(hydrochloride), CT-012002, RP-39937, L-ADR, LEU-DOX, Doxogenix L
Leurubicin, E-88/032(hydrochloride), CT-012002, RP-39937, L-ADR, LEU-DOX, Doxogenix L
流柔比星Chemical Name: (8S,10S)-10-[[3-[(S)-2-Amino-4-methylvaleramido]-2,3,6-trideoxy-alphal-L-lyxo-hexopyranosyl]oxy]-8-glycoloyl-7,8,9,10-tetrahydro-6,8,11-trihydroxy-1-methoxy-5,12-naphthacenedione; N-L-Leucyldoxorubicin; N-L-Leucyladriamycin; (8S-cis)-6,8,11-Trihydroxy-8-(hydroxyacetyl)-10-[2,3,6-trideoxy-3-(L-leucylamino)-alpha-L-lyxohexopyranosyloxy]-1-methoxy-5,8,9,10,12-hexahydronaphthacene-5,12-dione
CAS No. 70774-25-3
项目整合开发状态: Phase I
项目研究机构: Medgenix (Originator)
合成路线:By condensation of doxorubicin hydrochloride (I) with L-leucine N-carboxyanhydride (II) in a buffered aqueous solution at pH 10.2.
📌 参考资料/链接：
参考文献标题:Novel doxorubicin derivs.,process for their preparation and pharmaceutical compsns
文献作者:Baurain,R.; Trouet,A.(Medgenix Group)
参考来源:BE 0869485; DE 2930637
📄 详细内容
合成路线:By condensation of doxorubicin hydrochloride (I) with L-leucine N-carboxyanhydride (II) in a buffered aqueous solution at pH 10.2.
参考文献标题:Leurubicin
文献作者:Prous,J.; Castar,J.
参考来源:Drugs Fut 1993,18(2),116
产品链接: CAS No. 70774-25-3››